Trying to get your guts up can take some time and come from a variety of sources. Guts will help you stand up to people in conversations. To have sex with a woman in such a way so as to figuratively or literally disrupt her visceral organs. The implication is that the vigor of the. Definition of get the guts up in the Idioms Dictionary. get the guts up phrase. What does get the guts up expression mean? Definitions by the largest Idiom.